When we talk about replayability for a single player game we often exaggerate ourselves because it really comes down to personal favorites regarding that aspect. Hades is a game that puts this aspect upfront since death and failure are two cardinal fates that are mandatory for you to reach your goal. Blend it all with vastly addicting, deep but understandable role-play mechanics not to mention always lucrative Greek mythology and you have one of the most well crafted action rogue like hack & slash games there is to play right now.
I don't opt for anyone to be a fan of this genre to play Hades because the lore and inciting story are absolutely worthy for everyone's playthrough. Also there is the option for a God mode which adds to my previous statement if you just want to enjoy this painstaking journey without sweating too much!
It is a masterpiece, period. (Oh and did I mention how badass the soundtracks are?)