I have more hours in Aseprite than all of my games combined. I make all my work and personal projects in it, including my Steam profile. Tried few others simultaneously and this was most intuitive for me. It's customisable and allows scripts so if it's not fully comfortable to you, you can make it so. If what I wrote is not enough than take it from the croc:

When Hyper Light Drifter came out I was 33 years old and I had a boring desk job. I loved everything about the game but especially the artstyle. I told myself back then: "I want to make such beautiful things myself. I want to be a pixel artist".
So I've started to read everything about pixel art, study every tutorial, finish every online course I could find, and I practised everyday. I've joined online communities and listened to feedback from experienced artists and analysed their work.

I'm 40 years old now and I'm working in game industry as pixel artist.


Games are art.
Games are love.
Games change lives.

Thank you Heart Machine!