It's such a shame developers stopped supporting linux. Tried to run via proton and other alternatives but it keep crashing miserably. Used to be my #1 game... that's so unfortunate


Edit: I finnaly get it working. After some many attempts, the game can run with Repentance DLC only if you use "Proton Experimental". It will crash many times, but if you are patient and try many times, you can play it. You may see that the app is not responding, but that's ok. You have to wait and not close the window and the game will launch eventually. So there it is the temporary solution for you Linux users.

Edit 2: If you encounter lag issues in full screen, then do this: go to /.steam/debian-installation/steamapps/common/The Binding of Isaac Rebirth/resources/packed and create a file named options.ini.
Paste this code in it: After that, jump into /.steam/debian-installation/steamapps/compatdata/250900/pfx/drive_c/users/steamuser/Documents/My Games/Binding of Isaac Repentance and then modify the options.ini file. (obviously, this is another file with the same name) :

Until they give linux support back, please mind sharing this to reach out to people.
Hope that it works for you.