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(Intend to do an "dwarf fortress" style playthrough and was searching for a way to add the "drinks only alcohol" setting to it. I was already afraid that i would have to hack around in "bad hygiene" to make alcohol the only valid source of fluids.)
Depending on how it functions, most people would probably just avoid the drug altogether instead of taking that gene if the gene has a metabolic loss, and if the gene gives metabolic efficiency, that would basically end up being unbalanced free metabolic efficiency since there's no requirement to take the drug.
Drug immune- Can't get addicted but cannot be intoxicated at all