The KPGC10's successor, the KPGC110, was introduced in 1973 after its introduction at the 1972 Tokyo Motor Show. Powered by a 1,989 cc S20 inline-6 engine, the second generation of the GT-R delivered power to the rear wheels through a 5-speed manual gearbox. This car also had both front and rear disc brakes. The suspension was a semi-trailing ring arm setup and minor aerodynamic parts were added.

This model of the GT-R was also known as the Kenmeri Skyline, due to a popular advertisement featuring a young couple (Ken and Mary) enjoying the Hokkaido countryside. The advertisement later spawned a hit song by Buzz, and the tree featured in the advertisement later became a minor star itself.

A total of 197 cars were built by the end of its short production run. For the next decade, this was the last GT-R until the production of the R32 in 1989.