The Nuzlocke Run.
The most epic run-type for Pokemon games. It's creator, Nuzlocke, designed it for his latest replay of Ruby. And to go along with it, he drew comics. These comics produced a shitstorm, and a legend was born.

To attempt a Nuzlocke Run, you must adhere to the following rules:

Purist Rules:
-If a Pokemon in your party faints, you must release it.
-Every time you reach a new route, cave, etc., you must catch the very first Pokemon you see, regardless of your current number of party members. The Pokemon may sit within the box for an indeterminate amount of time as a backup.

/v/ addons:
-If you fail to catch the first Pokemon you see, either via it fleeing, knocking it out, or having no Pokeballs, you may not catch another. Tough shit.
-This means you can not catch a pokemon in a route you were in before you could catch pokemon. So no route 1, you were there before you had pokeballs.
-If a town you go to contains a body of water or a gift Pokemon like Bill's Eevee in G/S/C/HG/SS, that may be considered a Pokemon of a new area.
-You must nickname your pokemon so there is some sort of attachment. Each pokemon is a best friend to you, to see them die is heartbreaking.
-If your entire party faints, they all must be thrown away. If you have a pokemon left in a box somewhere, you may continue, otherwise you must start your game over.
-Treat pokeballs as rare artifacts; at no point can you buy more than one from each store. You should only use ones you find in the wild or are awarded.
-You are, under no circumstance, allowed to use items outside of battle. If you were poisoned on your last turn of the battle, you better hope to god theres a pokemon center nearby.

Want to chat with even more Nuzlocke fans such as yourself? Then check out the forums!

Nuzlocke Comics[www.nuzlocke.com]
Nuzlocke Forums[s7.zetaboards.com]