Type in 'blam' at any time while playing Grim Fandango for a little surprise.

In the hallway of the DOD there is a picture of a boat. If you look at in Manny says "Not that I have a choice, but I wonder if I would be happier working on a ship. Then again I'm so competitive I wouldn't be able to rest until I was Captain." At the end of year two on the ship he is just the cleaner, and then a year later he is the captain.

The moon at the harbour where Velasco is has a face. Or, try to 'Use' the moon, and Manny and Velasco will recite a poem.

Manny's surname "Calavera" is Spanish for Skull.

There are several characters throughout the game that when you try to pick them up (p key), they will give some funny responses:

• Olivia - Manny will say "Not Hector's girl!"
  
• Velasco - Manny will say "Hey sailor!", in a sweet and tempting voice
  
• Naranja - Manny will say "No more picking up sailors for me."
  
• Carla - After the fight with Carla, Manny can pick her up, asking if she's forgiven him. "Still in the anger phase," she says.

In the festival behind the balloon twister's tent during Year 1, Olivia can be seen in the crowd.

When Manny is in the giant cat stable, he will look down at the turds in the litter box. If you try to pick one up, Manny will just laugh and laugh.

Domino has told Pugsey and Bibi that Manny has a bone saw. If you "use" the Bust-All near them, Manny says, "Hey, kids, wanna see my bone saw?" They will burst into tears and screams.

At the end of the world, if you enter Domino's office and take out the scythe or the Bust-All, he will pull out his own gun and say, "Please put that away." However, if you pull out Pugsley's miniature hammer, Domino laughs and says, "OK, you can take out the tiny hammer."

In Toto's Parlour, next to the phone there is a poster of tattoo designs including Sam and Max and the Corley Motors logo from Full Throttle.

In year 2, when you cross the bridge under the Blimp, a short melody plays which is part of the opening theme to Secret Weapons of the Luftwaffe... an older World War 2 flightsim from Lucasarts (or Lucasfilm Games as it was known back then)

In the Blue Casket, while on the microphone, say "Anyone know where I can find some tools", and some of the guests mention a 'monkey wrench', which is a refence to a certain part of Moneky Island 2.

If you try going into the tunnel with the crocodile, Manny will say "Wow! It's a tunnel that opens onto a system of catacombs!", which is the same line that Guybrush says in Monkey Island 1 when he looks down the tree stump in the woods. This scene also appears in Monkey Island 3 when Guybrush sticks his head into the crack in the wall in the Goodsoup Family Crypt.