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Yes, Chem Toxin stacks drop off one by one, 2.6s after last stack application, one stack is dropped every 0.35s. And yes, the damage potential is very high, especially compared with other existing DoTs (the ADMs are also very high so that rending is less of a 'requirement').
Toxin Mania buffs the damage of DoTs as well, yes. You can find the full list of buffs that affect Chem Toxin's damage in the Chem Grenade section.
As Splater said, Soulblaze is covered in the Psyker guide. I haven't included the other DoTs in detail anywhere yet, might do so in the future.
Also, do you happen to know where I can find ADMs and info on the other DoTs like bleed and soulblaze? I'm curious how they compare (I know chem tox wins).