Borderlands® 4

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5 Best Harlowe Builds in Borderlands 4 (2025 UPDATED)
Av GigaGamer47 och 1 medverkande
Quick guide for picking a Harlowe build that actually works in-game, not just on paper. Short takes. Clear picks. You’ll leave with a plan for your skill points, augments, and weapons.
   
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TL;DR
  1. Dirty Bomb: Prime packs with CHROMA and detonate to flood the room with radiation. Hit Dirty Bomb and Demon Core, ride Neutron Capture, and spray with a fast Maliwan SMG. It ramps fast and melts bosses once rolling.

  2. Ties That Bind V2: Stasis chains, use Zero Point to entangle, then ricochet through rooms so damage shares across targets. Falling Bodies and Triple Point create big cryo spikes that feel like old Maya crowd deletes. It’s your safest mobbing plan.

  3. Neutron Capture Spam: Leveling path, keep CHROMA on cooldown, stack early crit and damage picks, and let Neutron Capture supercharge your guns. Simple loop, huge uptime, great for racing to key capstones.

  4. Cryo Stasis Starter: Early game, unlock Triple Point early, run a cryo gun, and lean on cooldown to keep Zero Point humming. Super forgiving while leveling, then it spikes when Freeze Frame and crit nodes come online.

  5. Nuclear Winter: Overshield dome, drop Flux Generator on enemies, stand inside, and scale damage off the shielded field. Pick the overshield and radiation nodes, then pull packs back into the dome. Steady clears, comfy solo, solid co-op value.
Harlowe: The Gravitar
Harlowe is a former Maliwan combat scientist who fights with three action skills and a trait that links enemies. Use Chroma Accelerator for damage windows, Zero-Point to lock targets, or Flux Generator for a portable zone that buffs allies. Entanglement makes damaged or affected targets share a slice of gun and skill damage, which is why her mobbing feels like classic Siren, just…techy.

5 Best Harlowe Builds (My Personal Favorites)


1. Dirty Bomb (Creative Bursts & Cosmic Brilliance)
Radiation-first DPS that snowballs off status effects.

Action Skill: CHROMA Accelerator

Core picks for Creative Bursts are Fuzzy Math, Elementary, Enriched, Glow Up, Chain Reactor, Test Subjects, Carry the One, Fissile Launcher and the Dirty Bomb with Demon Core as the capstone then add Neutron Capture to push action skill damage into your gun as bonus radiation.

Then add Cosmic Brilliance as a combo, prioritizing Action at a Distance, Momentum & Neutron Decay. Then use a High RoF Maliwan SMG in radiation for weapons.

This build snowballs single-target and AoE once Demon Core starts auto-irradiating anything you entangle & yes it shreds anything.





Source: Modified Dirty Bomb Build[www.wemod.com]



2. Ties That Bind V2 (Seize the Day & Creative Burst)
This is a modern spin on Amara-style chains.

Action Skill: Zero-Point

Open with Strange Attractor to ricochet bullets and mark crits as entangles, then chain Ripple Effect, Too Coolant for Schoolant, Concurrence, Control Group to spread stasis across rooms. Add Falling Bodies as a capstone to add a second stasis target and slams everything at once. Top it off with Parallel Circuit, Unstable Ice-otope & Triple Point for that big Cryo spikes on entangled enemies.

Combo it with Creative Burst prioritizing Cyclotron & Fuzzy Math, then use Jakobs Rifle or parts for innate ricochets that keep sharing damage.

This build focuses on Crowd Control first then damage afterwards because physics.





Source: Modified Ties That Bind V2 Build[www.wemod.com]



3. Neutron Capture Spam (Creative Bursts & Cosmic Brilliance)
I use this build mainly for leveling purposes only

Action Skill: CHROMA Accelerator

This build mainly focuses on spamming CHROMA on cooldown then riding the Neutron Capture buff for that radiation damage. During the early stage put the following points in order:
  • Cyclotron - 5
  • Neutron Capture
  • Elementary - 5
  • Enriched - 3
  • Test Subjects - 2
  • Poisoned Sun - 5
  • Chain Reactor - 3
  • Fissile Launcher - 2
  • Dirty Bomb - 1
  • Demon Core for Capstone

Use them until level 40 then respec and put the points above then allocate the following points post-40:
  • Test Subjects - 3
  • Practical Applications - 5
  • Field-Ready Prototype - 5

Post 40 respec - follow the initial skill point order above the line and then this one in addition:

Cosmic Brilliance
  • Momentum - 5 or Mains Hum - 5 if you prefer to be tankier
  • Neutron Decay - 5
  • Confirmative Reality - 3
  • Resonance Cascade - 3
Creative Bursts
  • Test Subjects - 3
  • Practical Applications - 4 / Highly Efficient if you want more defense / Get Up and Go if you want more movement speed

As for weapons, radiation guns are preferred but you can use anything that’s elemental and super potent as long as it has a high rate of fire because the higher it is the more Neutron Capture damage you do.





Source: Modified Neutron Capture Spam Build[www.wemod.com]



4. Cryo Stasis Starter (Seize the Day)
Another leveling build that mainly focuses on Zero-Point.

Action Skill: Zero-Point

This build clicks the moment you unlock Triple Point. You’ll entangle, deal any damage type, then get bonus cryo on top. Prioritize crit and cooldown picks to keep the loop tight, and run a cryo-rolled gun when you can. This path is forgiving early, then spikes hard once Triple Point and Freeze Frame are online. For Augments, you can either use Peer Review if you have a teammate or Strange Attractor if solo then switch to Cold Storage once you’ve unlocked it.



Source: Modified Cryo Stasis Starter Build[www.wemod.com]



5. Nuclear Winter (Cosmic Brilliance)
Build that focuses primarily on Flux Generator combo

Action Skill: Flux Generator

Drop it on top of enemies, stand inside, and scale damage off overshield. Core picks are Creative Overflow, Latent Charge, Mains Hum, Distribution Function, Decoherence, Refraction, Meltdown, Excited State & Runaway Reaction. Use Blue Giant temporarily as an augment for additional radius then switch to Nuclear Winter until you’re comfortable with radius management. Use Violent Horizons as capstone that adds ranged radiation pulls, which your Generator then drags back into its field.

Not the best for boss farming but this can give you a stable experience during solo and a strong co-op option that is also fun.



Source: Modified Nuclear Winter Build[www.wemod.com]
Optional Trainer Helpers (Use Responsibly)
  • Edit Skill Points - Quick-swap between these setups without grinding respec cash or levels. Handy when switching from boss hunting to mobbing.

  • Edit Money - Helpful for buying key equipment to make these builds work. Can either be guns or repkits or anything.



Source: Download Borderlands 4 Trainers Here For Free[www.wemod.com]
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