The game is very simple, in essence it is one of these Candy Crush or similar games where you match 3 equal elements and they disappear, giving you points.

After eliminating these elements, new ones appear at the top and the cycle repeats.

Like most of these games, the more elements you join in one move, the more points you will get as a combo.

This game has only 2 particularities:

1. The first one is that this game is 3D, so rotating one of the rings affects the whole cylinder as a Rubik's cube would do.
   
   
2. The second is that in this game you progress by making the chemical compounds at the bottom of the screen, and these are made by “destroying/putting together” the elements that you are asked for, which are “stored” until you have destroyed the chemical elements that make up the chemical compound.
   

We can rotate the rings horizontally or interpolate two elements vertically.

The objective of the game is to make the combos large enough so that by the time you have completed the list of chemical compounds (I estimate around 800-900) you have the highest possible score.

All achievements should be earned naturally before finishing a game, but there are ways to speed up this process with a few small tips I'm going to give you:

1. The first thing is to go to Settings and reduce the animation times to a minimum, this will save you a lot of time waiting for the pieces to reposition. It may seem insignificant but it is not, after doing thousands and thousands of combinations those seconds add up.
   
2. The next thing to do is to change the mouse mode to “two-button” mode where the right mouse button is used exclusively to move the rings of the cylinder. The reason for this is that many times you will click on an element and instead of moving the ring, you will interpolate two elements, making you lose time, especially when you are not looking at the screen.
   
3. As a last piece of advice I would recommend to turn off the music, my head was spinning after the first hour.

With all this ready, let's go to the gameplay

The 0 effort way I found was to right click and drag randomly to the right and left the rings 2,3,4 starting from the bottom, the reason for this is that these are the rings that get to add more pieces when the elements are destroyed, adding possibility of longer combos = destroy elements faster = move from compound faster.

The second and most important advice it is to abuse the “Shuffle” button, since in most cases it will give us a few more elements than we need to complete the compound. The only pity is that you have to wait 30 seconds between shuffle.

I started to watch Youtube videos on my mobile while I looked up every x seconds, to press the “Shuffle” and while the button reloaded, I made the rings rotate randomly without even looking at the screen. This allowed me to finish the game in just 4 hours. I've seen that many people usually need about 15h of gameplay to complete it, which seems to me a brutality, I don't think it's necessary.

Finally mention the issue of combos for combo achievements.
Don't worry, you will naturally get very high combos, the last achievement requires you to have a 2500 combo, and I can count up to 4-5 times in which pressing the mix button by accident I managed to pass up to 12000. Don't be in a hurry, it will come out before you finish the game.

With this method I got all the achievements in 4h.
I do not know why there are people who have completed the game and do not have all the achievements, this may be a product of a bug, previous versions, or that have achieved some achievements by cheating, but in my case, all the achievements I got them during my first game and using the method that I told you above.

I hope you found it useful and have a great day!
Take care

-Albert