By just playing the main story all the way through you will unlock the following achievements:

• 
  A New Suit: You will unlock this achievement after completing Main Quest 5: Good Men.
  
  When Peter and Harry find out about Dr. Connor's location, they go to save him and MJ. During their attempt to save the Doctor, Peter is wounded by Kraven and Harry accidentally saves Peter by giving him the Venom suit. After gaining the power of the symbiote and defeating all enemies in the area, you will receive the achievement.
  
  
• 
  Leave Us Alone: You will unlock this achievement after completing Main Quest 25: Don't Be Scared.
  
  After Harry gets infected again with the Symbiote and turns into Venom, you take control of him and start destroying the Oscorp building. Then you go to Time Square and fight with the hunters, and finally you end up with Kraven and you have to make him wish to die.
  
  
• 
  The Great Hunt: You will unlock this achievement after completing Main Quest 24: Anything Can Be Broken.
  
  After you find out what harm Kraven wants to do to Miles, you attack his safe house and fight with him to kill him, but at the last moment when you want to make his death wish come true, Miles comes and stops you. After a fight between Miles and Peter, Peter manages to separate the symbiote from himself and return to his normal state.
  
  
• 
  Medicine: You will unlock this achievement after completing Main Quest 20: It Chose You.
  
  After the fight between Peter and Lizard and turning him back into Dr. Connors, he tells Peter that the clothes he took from Harry is an alien and shows him the meteorite, which Peter loses control when he sees it and understands why Dr. Connors' hand was cut off. After Peter regains his senses, he refuses to abandon the suit and you get the achievement.
  
  
• 
  Another Way: You will unlock this achievement after completing Main Quest 23: No Escape.
  
  Miles was unconscious and captured by hunters in pervious quest and now he is looking for a way to escape from prison. He tries his best to survive by using all his skills, but in the end, he meets Mister Negative and Kraven will forces them to fight each other so that one of them survives. After the end of the fight and helping to Li to escape , you will receive the achievement.
  
  
• 
  I Quit: You will unlock this achievement after completing Main Quest 27: This Isn’t You.
  
  When you return to your home in Astoria, you see that Harry has arrived before you and is talking to MJ. After continuing the conversation with Harry, he turns into Venom and turns MJ into Scream. Now you have to fight with your lover and after defeating her you will get this achievement.
  
  
• 
  Heal The World: You will unlock this achievement after completing all 31 Main Story Quests.
  
  By putting end to chaos of Venom and making New York healthy, now Peter is ready for a quieter life and a little distance from Spider-Man. After seeing all these events, the story of the game will end and you will receive this achievement.
  
  
• 
  You're Gonna Need Help: You will unlock this achievement after completing Main Quest 01: Surface Tension.
  
  After defeating Sandman and handing him over to the police, you will receive this achievement.

Once you've completed the main campaign, it is recommended to then focus on the side content/story, which develop the story outside the main narrative and fleshes out certain characters even more. Concentrating on the side missions will get you the following achievements which includes the Friendly Neighbourhood Spider-Man requests which contain mini-stories in themselves:

• 
  My Community: You will unlock this achievement after completing Hard Bop.
  
  Hard Bop is a side mission that you must complete with Miles. It centres on Miles's mother, Rio Morales's efforts to open a Harlem community centre and exhibition. It's all about Harlem's musical and artistic history, and this run of side missions – rather intriguingly – involves an art heist. Complete them, and this achievement will unlock.
  
  
  You can activate the string of missions here by looking for this icon on the map:
  
  
• 
  Crimson Hour: You will unlock this achievement after completing It Was Meant For Me.
  
  This side story involves an old friend, familiar to players of the first Insomniac Spider-Man, who has had something of a change of direction in life. And a new costume. Anyway, in order to unlock this trophy, you need to trigger this side story, which you can find in the Financial District, called Where Have You Been? Once you have followed the quest line through, you will unlock this achievement.
  
  
  To kick this quest off, look for this symbol:
  
  
• 
  Data Collector: You will unlock this achievement after completing Target Identified.
  
  After Kraven enters the main story, you will see a slew of Hunter drones pop up all over the boroughs. Beating each one of these means using your Web Wings to chase a drone, staying in its slip stream to maintain your speed. All the while, you're downloading data from the drone. Check your map, and look for the drone symbols to hunt them down. Once you have all of them – there are one or two per borough – then you will unlock this achievement.
  
  
  They look like this icon on the map:
  
  
• 
  Friendly Neighbourhood Spider-Man: You will unlock this achievement after completing all FNSM requests.
  
  The Friendly Neighborhood Spider-Man requests are back, after being featured in Spider-Man: Miles Morales. You can use the FNSM app, and you will be able to see requests as they appear here. But they are also visible on the map. Complete all the FNSM requests, and you will unlock this achievement.
  
  
  They look like this icon on the map:
  
  
• 
  A New Adventure: You will unlock this achievement after completing Howard's FNSM request.
  
  Bring up the map, and then look for the FNSM request for "A New Adventure." The mission involves meeting up with Howard, the homeless fellow from the first Spider-Man, who loves and cares for pigeons. He wants you to find a new place for his flock to roost, as he is off on an adventure. Complete this, and you will unlock this achievement.

You can also focus on the various side activities before you progress with the main story; it doesn't matter that much which order you choose to do this in. If you go after the SUPERIOR achievement, which has you completing every activity in every district, then you will rack up a number of other achievements including the ones below.

• 
  New York, New York: You will unlock this achievement after completing all Photo Ops.
  
  Early on in the story, you will notice that the map is covered in camera icons. These work similarly to the landmark photos in the first game. Check your map for their locations. Or you can just try to catch them in open play. You swing around, you see a photo opp, take your camera out and take the shot. You will then contact Robbie Robertson and he will talk about life in New York city.
  
  
  The Photo Ops look like this:
  
  
• 
  Behind The Masks: You will unlock this achievement after completing all Mysteriums.
  
  To unlock this achievrment, you need to complete all of the Mysteriums that are scattered across the city. To access these challenges, you must first complete Main Quest 13. After that, 9 green gates will be added to districts, and you can experience these challenges by entering these gates. Each of the Mysteriums will challenge you in a different way. Some entail very specific objectives, such has throwing a certain number of foes from a roof within a time limit. You can attain Bronze, Silver, and Gold ratings on each one.
  
  
  They look like this icon on the map:
  
  
• 
  Grains Of Sands: You will unlock this achievement after completing all Marko's Memories.
  
  After your early confrontation with Sandman, in the first story mission of the game, you will unlock a series of Sandman's memories, which are scattered across the map. Complete all of these – there are one, sometimes two in each borough – and you will unlock this achievement.
  
  These crystals are actually Marko's Memories before the Kraven attack him, which were spread due to the hunters' torture. By breaking each crystal heart, a part of Marko's Memories will be told to you by the crystal and you will learn about his past. After finding all these 14 crystals, his peace returns to him, and he realizes that his daughter is safe and regrets his actions.
  
  
  They look like this icon on the map:
  
  
• 
  Seek And Destroy: You will unlock this achievement after completing all Hunter Bases.
  
  Hunter Bases are very similar to the Fisk contruction sites in the first Spider-Man: they are enclaves of enemies that you can web up and thump in the nose. You can do this stealthily, or you can go in spoiling for a brawl. After Kraven makes his appearence in the story, these bases will appear on the map. Complete all of these bases, and you will unlock this achievement.
  
  
  The bases look like this icon on the map:
  
  
• 
  Funky Wireless Protocol: You will unlock this achievement after solving the origin of the Spider-Bots'.
  
  Across the map, there are a number of Spider-Bots, all of them with distinct themes and colour schemes. (There is even a little J. Jonah Jameson Spider-Bot!) They don't show up on the map, so you have to find them while you're out exploring. You will see, however, that they do appear on your mini-map, in the bottom-right corner of the screen.
  
  
  Here is the icon for the Spider-Bots on your mini-map:
  
  Once you have picked up one of these icons, all you need to do is follow it until you see the telltale shimmer effect. These purply shimmers give away the location of each Spider-Bot as you get in their vicinity.
  
  
  The shimmer looks like the above.
  
  
• 
  Foundational: You will unlock this achievement after completing all EMF Experiments.
  
  The EMF Experiments pop up after Harry introduces Peter to the Emily May Foundation, in the main story. Once they do, you will be able to go about solving each one. Similar to Harry's environment challenges from the first game, these have you solving DNA sequence puzzles, catching fish to gene splice them, and watering crops. You will need to complete all of them to unlock this achievement.
  
  
  The EMF Experiment icons look like this:
  
  Once you have attained all these collectable achievements, you will amass a lot of components, and these can help upgrade your abilities and acquire new gadgets. For example, Kitted Out achievement, To the Max achievement can both be attained by purchasing all the available suits and fully upgrading your gadgets.
  
  
  More info explaining how to unlock All Suits on Part 2 - Continued: Collectathon!
  
  
• 
  Kitted Out: You will unlock this achievement after purchasing all Available Suits.
  
  Spider-Man 2 has 68 Suits, which are equally divided between Peter and Miles. All Suits are not entirely new as some of them have been added from previous games with some new extraordinary details. The Suits tab will be added to the Menu after Main Quest 03 and will allow you to choose Suits and also change the color of it.
  
  
• 
  To The Max: You will unlock this achievement after purchasing all Gadget Upgrades.
  
  There are 5 gadgets in the game and each of them needs to be upgraded 5 times to be fully upgraded. Tokens and Tech Parts needed to upgrade these gadgets are obtained from finding collections and completing districts. 2 of these gadgets are available from the beginning and the other 3 can be purchased from the gadgets tab in the menu as you progress through the story.
  
  To fully upgrade all gadgets, you need the following items:
  
  
• 4,495 Tech Parts
  
• 28 City Tokens
  
• 76 Rare Tech Parts
  
• 31 Hero Tokens

This game has 14 types of collectables that are distributed in 14 districts and each of them has its own achievement. None of them are missable and you can collect them all after finishing the story. Most of these collectables are not available from the beginning of the game and you will get access to them as you progress in the story. The important thing about collectables is that each district allows you to fast travel to it by finding 60% of its collectables, and before that you have to travel all the way by yourself, also you can see the number of collectables you found by moving the marker on each area. There are a Total of 160 Collectables:

• 23x Photo Ops
  
• 11x Hunter Blinds
  
• 4x Hunter Bases
  
• 43x Spider-Bots
  
• 10x Mysteriums
  
• 2x Cultural Museum Missions
  
• 9x Unidentified Targets
  
• 10x Symbiote Nests
  
• 14x Marko's Memories
  
• 9x EMF Experiments
  
• 6x FNSM Requests
  
• 4x The Flame Missions
  
• 5x Brooklyn Visions Missions
  
• 10x Prowler Stashes

There are a few achievements that you will passively acquire by just playing the game, such as:

• 
  
  Resourceful: You will unlock this achievement after acquiring 10,000 Tech Parts.
  
  You receive Tech Parts for completing side activities, such as random crimes in the street and side missions and stories. Bring up your map, and you will be able to see the activities around you, and you can also see what parts those activities will give you.
  
  
• 
  
  Amazing: You will unlock this achievement after reaching Max Level.
  
  If you concentrate on the main story first, that will net you big XP rewards. Then go about completing side missions, along with the Friendly Neighborhood Spider-Man requests. These have large XP rewards. Hoovering up side activities and clearing out all of the boroughs (see Superior achievement) will have you reaching max level before you reach the end of the game, and this achievement will unlock.
  
  
• 
  
  Stylish: You will unlock this achievement after equipping your First Suit Style.
  
  Navigate to the Suits tab, in there, pick a suit you like, then craft that suit's alternate styles (not all suits have suit styles only those with a star icon have suit styles). Think of them like colour variants within each suit's design. Pick a style, then select it, and this achievement will unlock.
  
  
• 
  
  Evolved: You will unlock this achievement by defeating 100 enemies with Evolved Venom Abilities.
  
  This achievement is for Miles because Evolved Venom Abilities is for him.
  
  At the beginning of the game, all of Miles' Abilities are orange, but as the story progresses, these Abilities become stronger and become blue. For this achievement you have to defeat 100 enemies with these new Abilities. (It doesn't matter if you hurt them, you need to give them the last blow that will lead to their defeat).
  
  
  Icon

  Ability

  Activation

  

  Chain Lightning

  L1 (LB) + Square (X)

  

  Thunder Burst

  L1 (LB) + Triangle (Y)

  

  Galvanise

  L1 (LB) + X (A)

  

  Reverse Flux

  L1 (LB) + Circle (B)
  
  
• TIP: Avoid farming this achievement by using manual saves as these will not be counted.