This game seems to dislike 16:10 resolutions, but will still force on first launch the same resolution of your Windows desktop... hence if you use a non-16:9 resolution (e.g. 2560x1600 16:10), you'll notice once in-game you have no mouse cursor, no bottom inventory pop-up etc., completely invisible!

This fix aims at removing 16:10 (and possibly other resolutions) buggy support in the game: it will be forced to 16:9 resolutions only (e.g. in my case 2560x1600 --> 2560x1440, nearest 16:9 resolution) so mouse cursor, inventory etc. will be actually visible and working once again!

Use a hex-editor (free offline tool like HxD, or online: https://hexed.it/ ) on the file "Yesterday Origins\YesterdayOrigins_Data\globalgamemanagers", and change at hex-address $11CA (4554 in decimals) just one byte: $01 --> $00 (from 01 to 00).

Done!
Now the game aspect-ratio support will be limited to 16:9 resolutions, automatically fixing the missing cursor and UI, invisible with a non-16:9 resolution.

Tested with Windows 11 23H2, i9-13980HX, 4090 laptop 16GB 175W, 2560x1600 16:10 240Hz G-Sync. Game version: GOG (but "globalgamemanagers" file should be the same for Steam, let me know in case it's not).

P.S.
If still fails on next launch after the patch, try to delete settings file "%AppData%\..\LocalLow\PenduloStudios\Yesterday Origins\YesterdayOriginsConfig.yo".