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Top 10 Synergy Combos in Risk of Rain 2 by DisputedOrigin YT
By Crow
Dive into the ultimate guide showcasing the top 10 item synergies in Risk of Rain 2! This guide uncovers the most powerful and unique item combinations that can turn your run into a legendary experience. From obscure and underrated pairings to game-breaking powerhouses, each synergy is detailed with its effects, strengths, and the best situations to use them.

Why It's Interesting:

Comprehensive Coverage: We explore a variety of item combos, ranging from early-game essentials to late-game dominators.

In-Depth Analysis: Each synergy is broken down to understand how the items interact, making it easy for both beginners and seasoned players to grasp.

Pro Tips: Learn the nuances of stacking items and optimizing your build for maximum efficiency and carnage.

Visual Examples: Accompanying gameplay examples demonstrate the sheer power and effectiveness of each combo.
This guide covers the top 10 item synergies in Risk of Rain 2, focusing on combinations that enhance damage output, survivability, and utility. Whether you're aiming for higher Monsoon clears or just want to have fun with some wild builds, this guide has something for every survivor. Join us as we explore the best ways to synergize your items and dominate the alien planets of Risk of Rain 2!
   
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Created by
Crow
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Category: Loot
Languages: English
Posted
10 Aug, 2024 @ 1:43pm
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Guide Index
Overview
Introduction 
10. Squid Pup + Remote Caffeinator
 
9. Gasoline + Ignition Tanks
 
8. Will-o'-the-Wisp + Ukulele
 
7. Poly Loot + Plasma Shrimp
 
6. Head Stompers + Wax Quails
 
5. Shatter Spleen + Crit Items
 
4. Watches + Crit + Armor Piercing Rounds + Crowbar + Focus Crystal
 
3. Forgive Me Please + Soulbound Catalyst
 
2. Spinal Tonic + Gesture of the Drowned
 
1. Spare Drone Parts + Empathy Cores
 
Comments
Introduction
Introduction

Welcome to the Risk of Rain 2 Item Synergies guide! This guide is designed to help you understand and maximize the potential of various item combinations in the game. By leveraging the synergies between different items, you can enhance your gameplay experience and achieve greater success in your runs. The information provided here is sourced from the insightful video by DisputedOrigin, and it has been converted into a written format for easier reference.

In this guide, you will find detailed explanations of the top 10 item combinations, each accompanied by a description of why they are effective. Whether you're a seasoned player or new to Risk of Rain 2, this guide will provide valuable insights into optimizing your item builds for maximum efficiency and power.

Let's dive into the top 10 item combos that can turn the tide of any battle in your favor!
10. Squid Pup + Remote Caffeinator
Squid pup spawns a squid turret every time you open an interactable. Squid turrets were buffed to have increased knockback force and attack speed. They scale their damage with the enemy's level, making their damage consistent. With Remote Caffeinator, not only does buying drinks spawn squid turrets, but it heals them as well, creating a powerful synergy with increased survivability and consistent damage output.

9. Gasoline + Ignition Tanks
Gasoline creates an explosion burning nearby enemies every time you kill an enemy, and Ignition Tank makes those burns three times stronger. Stacking gasoline increases both the radius and duration of the burn. High stacks of these can screen wipe entire stages, making this synergy extremely powerful for clearing large groups of enemies.


8. Will-o'-the-Wisp + Ukulele
Will-o'-the-Wisp creates an explosion dealing damage to nearby enemies when you kill an enemy. Ukulele chains lightning to three nearby enemies with a 25% chance, dealing 80% of the damage of the proc. The wisp explosions often hit multiple enemies at once, chaining the explosion damage onto ukuleles for a much larger area of effect blast. Adding Meat Hook can make it even stronger by pulling enemies into the explosions.


7. Poly Loot + Plasma Shrimp
Poly Loot, the corrupted ukulele, hits the same enemy multiple times, turning an area of effect item into a single target powerhouse. Plasma Shrimp turns 10% of your health into shield and fires missiles on every hit as long as the shield is up. Shrimp ignores the proc coefficient for these items, resulting in insane damage multiplication. With ICBM, it gets even crazier, firing out three shrimp on every poly loot proc, creating massive damage output.


6. Head Stompers + Wax Quails
Head Stompers increase jump height and create a kinetic explosion on hitting the ground, dealing massive damage from max height. Wax Quail provides a large vertical boost when jumping on a slope, allowing you to reach max height easily and use the Head Stompers' powerful explosions more effectively, resulting in devastating area damage.


5. Shatter Spleen + Crit Items
Shatter Spleen causes critical strikes to bleed enemies, and bleeding enemies explode on death. The explosion scales with the enemy's health, making it extremely powerful against high-health enemies. Combining this with crit items that increase your critical hit chance ensures that you'll consistently apply bleed and trigger massive explosions, leading to high damage output.


4. Watches + Crit + Armor Piercing Rounds + Crowbar + Focus Crystal
These white items are damage multipliers that enhance each other. Watches increase damage, crit items increase critical hit chance, armor-piercing rounds increase damage against bosses, crowbars increase damage against high health enemies, and focus crystals increase damage to nearby enemies. Together, they create an incredibly consistent and powerful damage output, providing synergistic damage amplification.


3. Forgive Me Please + Soulbound Catalyst
Forgive Me Please activates your on-kill effects, while Soulbound Catalyst lowers equipment cooldown on kills. This creates a feedback loop, allowing you to spam powerful on-kill items like gasoline, ignition tanks, will-o'-the-wisps, and ceremonial daggers, resulting in the best late-game damaging equipment.

2. Spinal Tonic + Gesture of the Drowned
Spinal Tonic provides a massive stat boost but has a chance to give you a debuff that decreases all your stats permanently. Gesture of the Drowned decreases equipment cooldown, making the tonic’s activation automatic and continuous. This combination ensures you only get the positives of the Spinal Tonic, doubling your base stats and making the game significantly easier with continuous powerful buffs.


1. Spare Drone Parts + Empathy Cores
Spare Drone Parts spawn an attack drone and enhance other drones with a chaingun and missile launcher, making it one of the best items in the game. Empathy Cores spawn two soless probes that gain attack power with every ally, creating an incredibly dominant and powerful combo, especially effective in speedruns and capable of carrying a run by itself with overwhelming drone firepower.