In the taskbar, search for Windows Security and open it.

Now, open the App & browser control Tab and open Exploit protection settings at the bottom of the window.

Next click Program settings, then Add program to customize and select "Choose exact file path".

Now, navigate to the Fallout folder and choose falloutwHR.exe

Next, find it on the list and hit Edit

Now, go down the entire list and check Overide system settings on every category.
Also, make sure to switch everything is switched to Off, if it isn't switch it back.


Finally, hit Apply and the game should finally work!

Many thanks to /u/BreakinBenny on reddit for finally helping me find this fix!

I was going crazy for weeks looking for this!

Also, let it be knows that Win11 loves to screw with older games so the exact layout of the settings might look a little different for you. As if it isn't enough that this glitch only seems to be affecting certain PCs.

You may have to poke a little bit to find your Exploit protection settings.
It seems to be called Vulnerability Safeguards in some versions of Win11.

Another thing is that you have to do this for any mod EXEs also.

Anyway, happy travels dweller!