"We take on the insanely broken Challenge 45, aka Delete This, where every item is a randomly generated glitch.
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More of the best indie games from Randomise User! In this let's play Binding of Isaac Repentance gameplay we take on Challenge 45: Delete This, where the goal is for Isaac to beat ??? in the Chest. But every item has random effects, which may help you, kill you, or just annoy the hell out of you!

See highlights of multiple runs as we try to beat Challenge 45: Delete This, picking up pink handles, visiting I Am Error more than any man ought to, finding an item that summons so many enemies it breaks, starting a run with a room of infinite items, and finally growing up to face our worst fears.

Watch more Isaac Repentance gameplay: https://www.youtube.com/playlist?list=PLLvo6-XrH1fn_km3-m9Y-tIfaIoPSpgFa

From the wiki for challenge 45: "All items are randomly generated by randomly combining effects from other items in the game. Item sprites and text are randomly generated as well, providing no information on what each item does. The theme of each area, its obstacles per area, and music are randomized."

Binding of Isaac Repentance on Steam: https://steamproxy.net/steamstore/app/1426300/The_Binding_of_Isaac_Repentance/

Chapters in video:
0:00 Intro
0:31 Run 1
2:30 Run 2
7:44 Run 3
9:36 Run 4
10:59 Run 5

Official gameplay description: "A game too big to be called a sequel: Repentance takes Isaac to new heights of roguelike dungeon adventure, as the brave boy descends into the basement for his greatest challenge yet! Isaac's new quest takes him to unknown places he's never been, filled with horrible new enemies and bosses, weapon combos you've never synergized before and items he's never seen... unholy terrors from his wildest dreams and worst nightmares!"

Developed by: Nicalis / Edmund McMillen
Version played: Repentance DLC
Repentance release date: 31 March 2021

More related videos: #IndieGames #BindingOfIsaac #BindingOfIsaacRepentance

Thanks for watching this let's play Binding of Isaac Repentance gameplay review! More from Randomise User, home of the best indie games:

► Indie gameplay videos 2021: https://www.youtube.com/playlist?list=PLLvo6-XrH1fntHk2GcreqA11dNPs2FCG8
► The best alphas & prototypes: https://www.youtube.com/playlist?list=PLLvo6-XrH1flWq5KRBP8GhUqcGxJT5cPB
► All Starbound videos: https://www.youtube.com/playlist?list=PLLvo6-XrH1flHOb_x1j6HTr5aWm9_5rRV
► Older gameplay (2014-2020): https://www.youtube.com/playlist?list=PLLvo6-XrH1fnvqfQI4mhyXJu5Y7hcS5vC"