This guide show you how play RE5 Splitscreen on your PC
Remember splitscreen support only with 2 gamepads its very hard set-up P1 keyboard+mouse and P2 on Xbox controller
So....

1. From your Steam 'LIBRARY' list, right-click on Resident Evil 5 / Biohazard 5 and select 'Properties' Select the 'BETAS' tab.
Select "original - Original GFWL version" from the pull-down menu and click CLOSE. Steam will downloading original RE5
2. Download this splitscreen file http://www.mediafire. com/file/dm1kttyl2ia6r3c/splitscreen_para_RE_5_por_Jorsh933.rar/file
( type the link into a search engine together) and extract it into your gamefolder
3. Now connect 2 controllers and simply start Splitscreen icon as admin and choose RE5 Direct x10 version ( it works better ) now you play in Split/Screen ;)
4. Enjoy