A few videos will be linked to supplement the advice on easing the grind for specific achievements. Credits go to the original uploaders.
This guide will also cross-reference a few other guides as needed, including Kracienator's excellent map guide:
https://steamproxy.net/sharedfiles/filedetails/?id=1369898689
After browsing through the game's discussion threads, the conditions for a few achievements were changed/reworded over the game's lifetime from Early Access to its "formal" release on Jul. 13, 2018. These will be noted as outdated information with the current conditions as appropriate.
It goes without saying, but there will be major spoilers throughout the guide.

Jul. 18, 2018: Guide published.
Jul. 19, 2018: Some editing fixes.
Jul. 23, 2018: Someone got confused over Kumasith's bad ending. Oops. Also, turns out Very hard mode also unlocks on Lunatic. Thanks Astral!
Jul. 24, 2018: Fixed 'Flawless' being written as 'Mastery'. Thanks Pootis McPootBird.
Aug. 05, 2018: Added another method for the combo achievements. Kudos to EnDDarK!

These achievements cannot be missed, as they are required to progress the game.
Soulreaper
Fight Soulreaper
The very first boss "fight" in the game, and the only one you're expected to lose.

Esgonian general
Defeat Esgonian general
The main boss of Brocleyshire.

HMWV
Defeat HMWV
The "mid-boss" of Mid Mythrilia. Not recognized as a boss on map.

Maximillian II
Defeat Maximillian II
The first boss of Mid Mythrilia.

Kumasith
Defeat Kumasith
The second boss of Mid Mythrilia.

Headless horseman
Defeat Headless horseman
The first boss of the Wesandyth Kingdom.

Santiago
Defeat Santiago
The second boss of the Wesandyth Kingdom.

Duel
Stop Soulreaper
The second boss of the Northern Border, and the second fight with the Soulreaper.

Ground shaker
Defeat Ground shaker
The first boss of the Glizzian Area.

Shroom prime
Defeat Shroom prime
The second boss of the Glizzian Area.

Valerie
Defeat Valerie
AKA Dragon Bones. The second of The Void's three final bosses, after the Soulreaper's third fight.
In addition to the game's proper normal and true endings, there are also five bad endings corresponding to specific bosses listed above.
If you already defeated any of the bosses without reaching their respective bad ending (assuming you saved past their fight), you won't be given another chance to get their bad ending until New Game+.
Soulreaper reborn
Defeat Soulreaper
You will get this bad ending if you manage to defeat the Soulreaper on the very first fight against her. It's possible, albeit potentially time-consuming to get this achievement without New Game+ due to her bulk and high damage this early in the game.
As for what happens next?
https://www.youtube.com/watch?v=Mau-qx3yEpU
Kumasith rampage
Failed to defeat Kumasith
This achievement corresponds to the Kumasith fight in Mid Mythrilia, not the Wraith fight in The Void.
The bear doesn't have an attack that hits nearly as hard as Maximillian II's bone wave, so this bad ending is easy to miss.
The count of piety
Failed to defeat Santiago
Dying to either form of Santiago will give this bad ending. Although Santiago's attacks are generally easy to read and dodge, the Count of Piety's homing lightning pillars, giant electric spheres, and The Devourer's electricity beam can easily kill you and net this achievement.
Dominator Holborn
Failed to stop Soulreaper
This bad ending is obtained by dying in the second fight against the Soulreaper. It's very easy to achieve as the Soulreaper can potentially one-shot you with many of her attacks in her second phase, or even in the shockwave transitioning to it!
Evolving fungus
Failed to defeat Shroom prime
Shroom Prime is a relatively passive boss, and doesn't hit particularly hard at this point of the game. Unless you stay inside the left mushroom's poison clouds long enough, this bad ending is the easiest to miss.
Note that you must die in the plot-mandated fight versus Shroom Prime; you cannot use its Rift fight, as that will just give the normal game over.
Family reunion
Achieve normal ending
Defeat the final bosses without going through the required steps for the true ending. The normal ending is distinguished by the post credit scene where Vivian's parents, Valerie, and Vivian disappear from the family dinner memory.
Seed of life
Achieve true ending
To summarize the process of obtaining the true ending:

1. From three rooms to the left of the Living Quarter Stela (the room right before the camp preceding Shroom Prime), there is a doorway elevated on the very top left corner. Enter it (you may need Heaven's Fall or Power Upper to reach the doorway), go right, and defeat the Evil Rag harassing the bear and bear child. You will get a seed from them as thanks.
   
2. There's an elevated doorway in the room before the Coffinhead Stela. Interact with the gate inside the next room; the game will tell you that you must hunt down the King of Flames, the Lord of Judgement, and the Frozen Queen to open the sealed gate.
   
3. Each demon lord is actually the true form of one of the three brats seen earlier in Broceley and Wheatawn. The King of Flames is to the right of the Throneroom Stela and adjacent to its Rift; the Lord of Judgement is two rooms left from the Seudor's Church Stela (this is the camp preceding the Headless Horseman), and the Frozen Queen is two rooms right from Bluereel Village's Stela. These bosses can be tackled in any order.
   
4. After obtaining the Heart, Club, and Diamond Keys, go back to the sealed gate in The Void and unlock it. Navigating to the end of this section of The Void will lead you to a fight against the
   Wraith of Kumasith. Defeat it, and she will bless the seed you got earlier.
   
5. Finish the game as you normally would.

The true ending is distinguished by the post credit scene where Vivian is brought back to life from The Void because of the Mother Bear-blessed seed's sacrifice, which is then planted and grows into a sapling.
Fallen Kumasith
Defeat Fallen Kumasith
AKA Wraith of Kumasith. If you're going for the true ending, you can't miss this achievement.

Very hard mode
Clear the game in Very Hard difficulty
The game has four difficulties as of this writing: Normal, Hard, Very Hard, and Lunatic. These difficulties change how much damage enemies inflict, but otherwise don't appear to do anything else.
With some patience, it's possible to finish a fresh game on Very Hard; another option is to change difficulties to Very Hard on New Game+, as the damage difference won't be game-changing until The Void. Despite the wording of the achievement's description, you can also unlock it by clearing the game on Lunatic.
Outdated information: Prior to June 1, 2018 update, the game's difficulties were Easy, Normal, and Hard, and you had to finish 'Hard' mode to get this achievement.

Achievements related to filling out parts of the in-game Note section, or completing a collection.
Explorer
Activate all Stelas
The 'Stelas' are one type of the save points scattered through out the game. Once you interact with a Stela (exploring a room with a Stela is enough to count towards the achievement), you can warp back to that room from another Stela. The majority of the game's Stelas can't be missed as they're positioned along the main story path, except for the Joker Key-locked Dungeon of The Decayed and Shadow Path. There are 18 Stelas found across the game's 6 regions:

1. Brocley: Starting village
   
2. Esgonian Junction: The room below the border to the Wesandyth Kingdom
   
3. Throneroom: The room with HMWV
   
4. Wheatawn City: Right outside the city's gates and before the Northern Border
   
5. Deep in the Cemetery: Two rooms to the left of the Headless Horseman's camp
   
6. Seudor's Church: The room after defeating the Headless Horseman
   
7. Church Tower: Deep inside the Church, two rooms to the left from the freefall
   
8. Halindle Cave: Along the path to Bluereel Village (5 rooms to its left)
   
9. Bluereel Village: Borders the Glizzian Territory and the path to the Magnus Workshop
   
10. Magnus Workshop: The room after defeating the Colossus
    
11. Glizzian Territory: Along the long path towards the Pantry
    
12. Living Quarter: The room to the right of the gate to The Void
    
13. Deathforest: The room on the upper-left of The Void's first large, vertical room
    
14. Coffinhead: The room right before village of ghosts
    
15. The Living Hell: Along the path to the final boss fights, 5 rooms away
    
16. Dungeon of The Decayed: Right before the eponymous boss rush
    
17. Shadow Path: Along the way towards the Dungeon of The Decayed
    
18. Wall of Origin: Right before the final boss fights

Outdated information: Prior to June 9, 2018 update, this achievement required discovering all of the rooms in the game's six regional maps.
True runeswarden
Acquire all skills
With the exception of Impulse Blade and Dimensional Swords, all skills are learned by acquiring their corresponding Stone Plate. There are 10 skills in total (citing Kracienator's maps for each):

1. Impulse Blade: You start with this skill.
   
2. Heaven's Fall: Stone Plate: Spiral. On a side path in the Brocleyshire battlefield: from the battlefield's camp, go up, right, up again, then left. [C2]
   
3. Power Upper: Stone Plate: Rising. In the fork that leads up to the Throneroom, go left into the library. The Chest is tucked away on the top right corner of that room. [C4]
   
4. Force Unleash: Stone Plate: Overflow. On the right, Rusty Key-locked door in the room with lever-locked blockades. [C5]
   
5. Shining Assault: Stone Plate: Assault. A reward for defeating the Headless Horseman. [C2]
   
6. Wyvern Attack: Stone Plate: Aerial. In the very top-left corner of the "middle" section of the large vertical room of the church. This skill tends to be forgotten because its chest is unreachable without some clever use of the Double Jump, Air Dodge, and either Heaven's Fall or Power Upper [C4]:
   https://www.youtube.com/watch?v=Jm6h44IhIG0
   
7. Mirage Storm: Stone Plate: Mirage. In a small cave near Bluereel Village: from the village, go down, then enter the cave as you move left, then keep going right. [C1]
   
8. Tornado Slash: Stone Plate: Tornado. The room connected to another room off to the middle-left side in the Pantry's large vertical room. [C3]
   
9. Polar Strike: Stone Plate: Strength. Connected to the mid-left room by the large vertical room to the right of Coffinhead. [C2]
   
10. Dimensional Swords: Fully max out the Runeswarden Ability at level 10, which costs 99999 Mana (after paying the doubling mana costs for the other 8 levels)

Gourmet
Acquire all recipes
To unlock a recipe, you must purchase the food from a chef. There are 12 recipes distributed among the 6 regions' chefs:

1. Fried Egg: Brocleyshire
   
2. Salad: Brocleyshire, Wesandyth Kingdom
   
3. Fried Bacon: Mid Mythrilia
   
4. Magnus's Poached Egg: Mid Mythrilia, Wesandyth Kingdom
   
5. Glizzian Sausage: Wesandyth Kingdom
   
6. Joint Roast: Wesandyth Kingdom, The Void
   
7. Grill Plater: Wesandyth Kingdom, The Void
   
8. Tomahawk Steak: Wesandyth Kingdom, The Void
   
9. Burger Patty: Northern Border
   
10. Beef Tartare: Northern Border
    
11. Crumble Pie: Glizzian Area
    
12. Mythrilian Salad: The Void

Slayer
Unlock all entries in Monsterpedia
There are 80 different monsters to kill in the game, including the 19 bosses, a few monsters that spawn exclusively from bosses, and the Hen. You can always go back to fight some of the bosses again through their Rift; this is particularly helpful with filling in the Groundshaker Grub's entry, as it can glitch out and spawn in an 'unkillable' state in the normal Groundshaker fight, which never happens in Groundshaker's Rift (mind the Rift grubs' bulk).

1. Esgonian General (Boss)
   
2. HMWVictory (Boss)
   
3. Maximilian II (Boss)
   
4. Spirite of Kumasith (Boss)
   
5. Headless Horseman (Boss)
   
6. Count of Piety (Boss)
   
7. The Devourer (Boss)
   
8. Colossous (Boss)
   
9. Groundshaker (Boss)
   
10. Master Shroom (Boss)
    
11. Wraith of Kumasith (Boss)
    
12. Soulreaper (Boss)
    
13. Soulreaper (Devil Form) (Boss)
    
14. Dragon Bones (Boss)
    
15. Holborn, The Dominator (Boss)
    
16. Hen
    
17. Raven
    
18. Piglet
    
19. Boar
    
20. Stag
    
21. Jackal
    
22. Alpha Wolf
    
23. Lone Wolf
    
24. Skeleton Warrior
    
25. Blood Champion
    
26. Holy Bones
    
27. Border Guard
    
28. Male Zombie
    
29. Female Zombie
    
30. Bloat Zombie
    
31. Esgonian Soldier
    
32. Esgonian Archer
    
33. Executioner
    
34. Esgonian Armored Knight
    
35. Pit Dog
    
36. Plague Bomb
    
37. Freed Sinner (Maximilian II spawns these)
    
38. Long Shank
    
39. Exotic Corpse
    
40. Fire Elemental
    
41. Ice Elemental
    
42. Lightning Elemental
    
43. Turned Maiden
    
44. Turned Lady
    
45. Groundshaker Grub (Spawned by...Groundshaker, but tends to glitch in the normal fight)
    
46. The Eternal Mourner
    
47. Floating Head
    
48. Evil Rag
    
49. Rat
    
50. Plague Rat
    
51. Blood Mouse
    
52. Demonic Brute
    
53. Grim Champion
    
54. Ghost
    
55. Wraith
    
56. Bat
    
57. Vampire Bat
    
58. Hell Bat
    
59. Evil Eye
    
60. Arcane Eye
    
61. Legion
    
62. Blazing Claw
    
63. King of Flames (Boss)
    
64. Frost Raven
    
65. Thunder Beast
    
66. Lord of Judgment (Boss)
    
67. Homunculus
    
68. Burned Man (Colossus spawns these, but they're also found in The Void)
    
69. Golem
    
70. Lonely Heart
    
71. Demented Brain
    
72. Torn Stomach
    
73. Abandoned One
    
74. Ice Queen (Boss)
    
75. Paralyzing Shroom
    
76. Spiky Shroom
    
77. Vicious Shroom
    
78. Mad Bear
    
79. Parasitic Bear
    
80. Vivian's Shadow (Final boss of the Dungeon of the Decayed)

Runecraft master
Unlock all abilities
This includes all of Runeswarden's levels; without extensive mana farming (see Mana collector), you'll likely have some locked Abilities when you reach the final bosses.
Noted
Unlock all entries in Note
Specifically, the Journal part of Note. You can't miss this achievement as you finish the game with either ending.

Other collection-based achievements focused on obtaining specific items, gold, or mana.
Wealthy traveller
Collect 1000000 gold


Mana collector
Collect 1000000 mana


These two achievements can be done concurrently by grinding early game at the Throneroom, mid game in the Magnus Workshop Rift and Shroom Prime's Rift, and late game at two specific rooms in The Void:
https://www.youtube.com/watch?v=5EHFniIorcM
https://www.youtube.com/watch?v=x1jWQ0yb7Xc

Enhanced
Acquire a max ranked weapon or armour
To clarify, this means any weapon or armor drop that's already at the max 5 star rank, regardless of whether each slot is empty or has a rune. You'll inevitably get this achievement as you play, whether from monster drops or opening chests.
The truth
Acquire Sword of verum
The Sword of Verum is the final reward of the Dungeon of the Decayed, after defeating Vivian's Shadow. At max rank, it has 400 attack and the fastest attack speed of all weapons in the game.
Enhanced
Acquire a weapon or armour with 4 runestones
The older 'brother' of Enhanced. As with Enhanced, you must find a weapon or armor drop that is already at max rank, but the equipment's slots also have to contain 4 runes. If this sounds like an obnoxious RNG achievement, that's because it is. Nightly9's guide has some pointers on reliably getting this achievement. Get to save scumming!
https://steamproxy.net/sharedfiles/filedetails/?id=1408678374

The rest of the achievements that don't fit anywhere else.
Gone waste
Keep drinking potions
You know how there's a potion 'cooldown' that severely reduces the effect of potions consumed in that time frame? If you keep drinking potions in spite of the cooldown, you'll unlock this achievement.
Potion fever
Consumed 100 potions in total
Self-explanatory.

Demon hunter
Slay 666 monsters
Also self-explanatory. You could speed up this achievement's progress early on with enough farming.
Mastery
Achieve 100 combos


Flawless
Achieve 500 combos


Chain burst
Achieve 999 combos


These three combo achievements can be slowly, but safely obtained by wailing on the infinite health training dummy in Bluereel Village. (Advanced) Mirage Storm helps a lot as it does a sizable number of multi-hits overtime, and has a lower rage cost than Tornado Slash.
Another method suggested by EnDDarK is to use (Advanced) Tornado Slash in the Dungeon of the Decayed's slime room to gather and multi-hit the dense mob of slimes. You should minimize your sword's attack (preferably with the Bloody Moon) to avoid killing any of the slimes until you get the achievements.
I killed the chicken
Slay the chicken
Just kill one of the (abnormally bulky) Hens wandering Brocley village. They only run off after being attacked and any attack will juggle them. If you're trying to unlock Slayer, you can't miss this achievement. No, nothing else happens after killing a Hen.
Onion!
Acquire an onion from the chef in Brocley village
At the very beginning of the game, keep talking to the man outside the door to Brocley village's cafe, and he'll give you a free onion and this achievement. You can only do this before the first Soulreaper fight!
The Vagrant
Unlock all achievements
Unlock every other achievement in the game. Good luck!