I've been playing a lot of Streets of Rogue lately and have been experimenting with a lot of Mutators, unlocking the newer content, and experimenting some more. I recently stumbled upon a really good combination that keeps you on your toes.
Currently the only requirements are the Mutators to be unlocked (which I only think 1 is needed to be unlocked), but to use the full range of this gamemode, having unlocked the Cannibal and Zombie classes is also suggested.

The Mutators in Streets of Rogue are numerous and can lead to some pretty intense moments in the game. The combination of Mutators listed below make a really fast and hectic gamemode.

Firstly you should remove all of the disasters except War Zone. I will explain later on. Here's a list of what to remove;

• Remove - Bombs Dropping
• Remove - Hidden Bombs
  
• Remove - Radiation Blasts
  
• Remove - Ooze
  
• Remove - Shifting Status Effects
  
• Remove - Bounty
  
• Remove - Killer Robot
  
• Remove - Police Lockdown
  
• Remove - Riot
  
• Remove - Zombies

After removing all of those disasters you should move on to adding some of the core Mutators that make the gamemode hectic! Below is the list of what to add!

• Infinite Ammo (Common Weapons)
  
• Disasters Every Level
  
• Zombies Ate My Game Balance

That's it! Those are all the Mutators that make the gamemode great!

Not much else is required except the three classes Soldier, Cannibal, and Zombie. Although you do not initially start with the Cannibal and Zombie, they are both relatively easy to unlock. These three classes are not mandatory, meaning you don't absolutely need them but they are for the best experience.

You can also make it harder by not choosing either of these three and going with even a Slum Dweller to complete all missions in each level while avoiding your inevidable death by a Cannibal or Zombie! If you choose to play as a class other than one of the three listed above, I recommend using the Everyone Hates You Mutator since the Soldiers do not initially attack you unless provoked.

The outcome of the Mutators added results in Soldier, Cannibal, and Zombie classes to war against each other constantly and through every level. Removing all disasters except War Zone and making each level have a disaster means that each level will constantly bring out the Soldiers and Cannibals which usually end up fighting each other. The only difference is the Mutator Zombies Ate My Game Balance adds the Zombies class to the mix.

When you first launch your run, you will be notified that you are in a War Zone and to not get in the middle of it. Also having Zombies turned on makes it a three-way war all the time. It would be kind of difficult to survive unless you added Infinite Ammo! I suggest using Infinite Ammo (Common Weapons). This allows you to join the fight and have a higher chance of surviving as opposed to not having any bullets at all!

Finally, the Disasters Every Level is required to make sure the war continues even when you do! The Endless Mutator is completely optional but I recommend using it to keep the mode going for as long as your heart desires!

This gamemode is great the original way I created it to be, but it can be customized to suit your own tastes in a variety of ways. For example, you can remove the Infinite Ammo Mutator or even remove the allowance of melee weapons which will replace them with guns of equal value.

Experimentation is one of the great things about Streets of Rogue and I'd love to share with all of you the other possibilities you can build off of using this gamemode I created!

Here are some ideas on what you could add to the already-made list;

• Full Health for All
  
• Mixed-Up Environments
  
• No Melee Weapons
  
• Rogue Vision
  
• Time Limit
  
• Everyone Hates You
  
• Endless
  
• New Character Every Level (if you feel like having a huge challenge)
  
• Bodies Explode

Maybe you could remove one of these even?

• Infinite Ammo (Common Weapons)

Other classes you can try playing with that provide an equal or greater challenge;

• Hacker - Install Malware at start of each level, turns into Soldiers vs. Cannibals vs. Zombies vs. Robots
  
• Slum Dweller - Provides a base experience where you have nothing but default items. Survive by any means necessary!

Below is a list of issues found in the WARZONE gamemode.

• Currently, you cannot play this gamemode using the Cannibal class. There are no known workarounds as of yet.

Finally, if you have any ideas, thoughts, and/or suggestions on this gamemode please feel free to share!

Thank you for reading, hope you enjoy.