Alchemy Mysteries: Prague Legends contains 5 missable achievements and 10 that pop through natural progression. it is possible to 100% Alchemy Mysteries: Prague Legends in one playthrough, to do this you must start the game on advanced difficulty and you should not skip any mini game puzzles or Hidden object games (HOG's).

PART 1.
Contents:
- HoG #1, Mr Shwarzenberg's house, your bedroom, suitcase on the bed = 3m54s
- Puzzle #1 (Coloured balls door lock puzzle), Mr Shwarzenberg's house, office door on the balcony = 8m24s
- HoG #2, The office in Mr Shwarzenberg's house, desk in the office = 11m08s


PART 2.
Contents:
- HoG #3, Mr Shwarzenberg's house, your bedroom, false wall panel between door and wardrobe = start of the video
- HoG #4, Antique shop, chest by the front door on the left = 3m12s
- HoG #5, Mr Shwarzenberg's house, ladder in the living room = 7m13s
- HoG #6, Mr Shwarzenberg's house, your bedroom, suitcase on the bed, again (2nd time) = 9m11s


PART 3.
Contents:
- Puzzle #2 (Alchemy books), In the antique shop = Start of the video
- HoG #7, Mr Shwarzenberg's house, your bedroom, nightstand to the left of your bed = 5m59s
- Puzzle #3 (Hidden symbols on wall), Mr Shwarzenberg's house, living room wall with the animal heads = 9m09s


PART 4.
Contents:
- HoG #8, In the cafe, behind the counter = 1m36s
- HoG #9, The office in Mr Shwarzenberg's house, desk in the office, again (2nd time) = 6m08s
- HoG #10, Mr Shwarzenberg's house, ladder in the living room, again (2nd time) = 10m19s


PART 5.
Contents:
- Puzzle #4 (Clock face puzzle), The office in Mr Shwarzenberg's house = 0m04s
- Puzzle #5 (Hidden symbols), Cemetery graveyard = 4m52s
- Puzzle #6 (Rotating picture puzzle door lock), Cemetery tomb door =5m25s
- Puzzle #7 (Coffin name plate puzzle), Cemetery tomb = 6m58s
- Seal Puzzle #1, Coffin in the cemetery tomb = 8m13s
- HoG #11, Behind the bush in the street as you exit the cafe = 10m19s
- Puzzle #8 (Matching symbol disc puzzle), Mr Shwarzenberg's house, above the fireplace in the living room = 12m20s


PART 6.
Contents:
- Seal Puzzle #2, The fire place in the secret room = 2m45s
- Puzzle #9 (Maze puzzle), Behind the spider web in the secret room = 3m55s
- HoG #12, In the secret room, on top of the cupboard, opposite the spider web puzzle = 4m53s
- HoG #13, Mr Shwarzenberg's house, your bedroom, nightstand to the left of your bed, again (2nd time) 10m12s
- Puzzle #10 (Mannequin puzzle), Mr Shwarzenberg's house, your bedroom = 11m30s


PART 7.
Contents:
- HoG #14, Mr Shwarzenberg's house, your bedroom, false wall panel between door and wardrobe, again (2nd time) = 1m04s
- Puzzle #11 (Paw puzzle), Antique shop floor, left of the front door = 2m54s
- HoG #15, In the jail, skeleton = 6m29s
- Seal Puzzle #3, Jail window bars = 8m17s
- HoG #16, Antique shop, chest by the front door on the left, again (2nd time) = 9m31s
- HoG #17, In the cafe, behind the counter, again (2nd time) = 11m27s
- Puzzle #12, part 1 (Symbol maze puzzle), lock opens a secret compartment at the back of the cafe = 13m37s


PART 8.
Contents:
- Puzzle #12, part 2 (Symbol maze puzzle), lock opens a secret compartment at the back of the cafe = start of the video
- HoG #18, Cemetery, tomb doorway = 1m33s
- Puzzle #13 (disc picture puzzle), on the table in the lab = 5m45s
- HoG #19, In the laboratory, pots on the floor to the right of the table = 10m57s


PART 9.
Contents:
- Puzzle #14 (Prism light puzzle), in the laboratory, on the wall behind the table = start of the video
- Puzzle #15 (item matching puzzle), On the table in the laboratory = 0m32s
- Puzzle #16 (Gate puzzle), Cemetery gate = 2m10s
- Seal Puzzle #4, Coffin in tomb behind the cemetery gate = 2m35s