Arnim Zola has no natural superpowers, but he is a scientific genius and biochemist specializing in genetics and cloning. He is not only capable of creating exact clone copies of his "clients", he has also created monsters which are conditioned to do his bidding.

Zola's most noticeable feat was performed upon himself. He constructed a specially modified android body which lacks a head. Instead, Zola's face is located via holographic projection on his chest. Atop his shoulders is an ESP Box, a psychotronic device which he uses to exert his control over his monster creations. The ESP Box also lets Arnim Zola gain mental control over others, fire mental blasts, and transfer his consciousness into another android body. In a limited effect, the Box can also be used as an offensive weapon. Whenever his body is damaged or utterly destroyed, Arnim is able to send his personality to another one stored elsewhere, thus giving himself a form of immortality.