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Wesker is a former member of the Umbrella Corporation's Special Forces unit, who becomes a high-ranking executive within the company. He is portrayed as a highly intelligent and calculating individual with superhuman strength and agility, as well as a penchant for treachery and manipulation. He is often depicted as being at odds with the game's protagonists, particularly the series' main character, Chris Redfield.
Throughout the series, Wesker is involved in various nefarious schemes, including the development and use of bioweapons, and seeks to gain power and control at any cost.