-rep Foot Fungus

This text is spread for informational purpose only. I am not responsible if someone is injured while using this information. After all, information wants to be free.

Extract with six 500 cc portions of ether and evaporate the ether in vacuo to get an oil that crystallizes readily. Purify by convering to the picrate or fractionally distill, collecting the fraction at 224-225* at 714 mm vacuo. The tropinones can be used in the above formula (or in a formula that you have found elsewhere) to be converted to cocaine. Remember to recrystallize the 2-carbomethoxytropinone before converting to methylecgonine.

Let stand several days to get dibenzaltropinone as yellow needles. Yield: 15.5 g, 28%. Recrystallize from ethanol to purify. Tropinone. A solution of 12 g of chromic acid in the same amount of water (12 g) and 60 g of glacial acetic acid is added dropwise with stirring over a period of 4 hours to a solution of 25 g of tropine in 500 cc of glacial acetic acid that has been warmed to 60-70* and is maintained at this temp during the addition. Heat the mixture for a short time on a steam bath until all the chromic acid has disappeared, cool and make strongly alkaline with NaOH.

. Tropinone. To a solution of 25 g tropine, dissolved in 10 times its weight of 20% sulfuric acid are added 25 g of a 4% solution of potassiumpermanganate in 2 or 3 g portions over 45 min while keeping the temp at 10-12*. The addition of permanganate will cause heat (keep the temp 10-12*) and precipitation of manganese dioxide. The reaction mixture is complete in 1 hour. A large excess of NaOH is added and the reaction is steam distilled until 1 liter of distillate has been collected. The tropinone is isolated as the dibenzal compound by mixing the distillate with 40 g of benzaldehyde in 500 cc of alcohol and 40 of 10% sodium hydroxide solution.

Below is given a somewhat easier method of producing tropinone by the general methods of Willstatter, who was instrumental in the first synthetic production of cocaine and several other alkaloids. After reviewing this method, I found it to be simpler than the above in many respects. Tropinone. 10 g of pyrrolidinediethyl diacetate are heated with 10 g of cymene and 2 g of sodium powder, the reaction taking place at about 160*. During the reaction (which is complete in about 10 min) the temp should not exceed 172*. The resulting reaction product in dissolved in water, then saturated with potassium carbonate, and the oil, which separates, is boiled with dilute sulfuric acid. 2.9 g of tropinone picrate forms and is filtered. Here are two more formulas devised by Willstatter that produce tropinone from tropine. Take note of the yield differences.