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[Edit: Very old review, will be updated once possible]

GREEDIER MODE SUCKS IT'S TERRIBLE I HATE IT

With loads of new items and updated graphics, and now even mod support, The Binding Of Isaac: Rebirth is on a whole new level compared to its predecessor.

They have tripled the amount of collectables, such as trinkets, passives and activatable items. This can be further enhanced by mods.

Loads of new enemies and floors, allowing each run to be even more random, interesting and of course, challenging in its own ways.

More bosses, enemies and room variation, more characters..

All in all, it's essentially a remake of the original flash game, except expanded and improved in every single way imaginable! It even runs great! Especially great for the completionist who enjoys a challenge.