The SIG Sauer P250 is a semi-automatic pistol made by Sigarms (now known as Sig Sauer Inc. of Exeter, New Hampshire). Introduced in 2007, the hammer-fired P250 can be chambered in .22 Long Rifle, .380 ACP, 9×19mm Parabellum (9mm), .357 SIG, .40 S&W, and .45 ACP. The P250 chambered in 9mm was introduced to the North American market on November 7, 2007 followed by the .45 ACP compact model in February 2008 at the SHOT Show. The last of the models was introduced in late 2009.

In early 2014, the SIG P320 was introduced. This striker-fired descendant of the P250 continued the modular format and shares several of the same components including magazines and grip frames.

As of January 2017, the P250 was no longer listed online by SIG Sauer, except for a .22 Long Rifle version; no P250 was listed as of January 2018.