Most of the stuff coming up isn't worth all that much. A few Robot/Mech ones, some magic girl, Slice of Life, etc. A few I picked out here:

PHI-BRAIN: Kami no Puzzle - An interesting looking program with puzzles and intelligence taking a spotlight, from what I can see. Main character looks like a boring Naruto would-be, but the shows concept seems pretty good from what I can tell.

Shakugan no Shana - The third series of this. I only ever finished watch the first one, but it was well worth it. Something I would quite recommend watching, if only for the cuteness factor. :)

Boku wa Tomodachi ga Sukunai - Interesting sounding one here; a guy and a girl forming a club for people with no social skills. Loners, Arrogance, and the Insane all put into a mixing bowl from what I can tell. Romantic Comedy to boot, so should be interesting.

Last Exile: Fam, the Silver Wing - Steam Punk, kids with goggles and hats flying abstract planes. What more do I need to say?

This are just a few I picked out from the Animenewsnetwork, and gave a little research into. With the exception of Shakugan & Last Exile, I haven't actually watched any of these, but nonetheless, these are my picks for the upcoming.

If anyone has any contributions for recommendations, or other things you've seen, feel free to put them into the comments. Bear in mind that some sort of explanation is a given. I won't accept people just naming random animes - Gotta give a reason and description of some brief sort. (Like above.)