The Brotherhood of Nod, often known simply as Nod or The Brotherhood, is the primary force opposing the Global Defense Initiative currently. Ever since its first appearance in the mid-'90s, Nod has increased its power and has come closer to achieving its goals. It has been once described as a "religious movement, multi-national corporation and a nation-state, while actually being none of these in itself". Probably the closest definition of the Brotherhood may be that it is a techno-religious military order.

It is led by a mysterious and charismatic man known only as Kane. Their insignia is a black-rimmed red chamfered triangle enclosing a black curved scorpion's tail. Nod also employs a number of slogans, such as "Peace through Power" and "Brotherhood. Unity. Peace". The organization is also known as "The Brotherhood, The Ways of Nod, or ShaÆSeer among the tribes of Godan." While the word 'Godan' existed prior to the brotherhood, it is unknown which meaning of the term is specifically referred to, so the exact meaning is still unknown.

The name 'Brotherhood of Nod' may have come from the Hebrew word Noded (נודד) which means wanderer, and is also the verb of the word Nod. It may be referring to the biblical Land of Nod, to which Cain is exiled: "Cain went out from Yahweh's presence, and lived in the land of Nod, east of Eden."